![]() ![]() The 24-hour clock we have is important when it comes to our healthy fat, and we need to protect it as much as we can,” said first author Aleix Ribas-Latre, PhD, with the Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig in Germany.Īdditional UTHealth authors include Rafael Bravo Santos, PhD Baharan Fekry, PhD Zhanguo Gao, PhD Mikhail Kolonin, PhD Kai Sun, PhD Brad Snyder, MD Alaa M.T. You should also steer away from high-fat diets, which we have now shown destroys the rhythmic proliferation of our preadipocytes. “In an ideal world, everyone would maintain a normal sleep-wake cycle, and not eat during the wrong hours of the day, so not too late before bed or into the early morning. Eckel-Mahan says having fat in these areas can lead to Type 2 diabetes and insulin resistance. ![]() Depletion of adipocyte progenitor cells will not allow for healthy new adipocytes to be made within the tissue, ultimately causing defects in fat storage and excess lipid spilling over into other organs, such as the liver and muscle. Throwing off the circadian rhythm and eating a high-fat diet over time will deplete healthy fat cells, and the study suggests that this disruption may be difficult to reverse. “What we project is that over the course of our lifetime, these 24-hour variations in the proliferation of these cells is really important in maintaining healthy fat.” “We found that when we fed mice a high-fat diet, it increased the proliferation of preadipocytes and destroyed its rhythmic pattern,” said Kristin Eckel-Mahan, PhD, assistant professor with the Center for Metabolic and Degenerative Diseases at the Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases at UTHealth and lead author on the study. However, when investigators introduced a high fat diet, or changed the temporal patterns of food consumption so that mice ate equal increments of food during both the sleep and the wake phase, this 24-hour pattern of pre-adipocyte proliferation was destroyed. Researchers discovered that adipocyte progenitors undergo rhythmic daily proliferation throughout the 24-hour cycle under normal patterns of energy intake. ![]() A good quality diet and one that is consumed in a rhythmic manner (i.e., during our active cycle) is important in maintaining healthy fat, the researchers found.Īdipocyte progenitor cells mature into adipocytes – the healthy fat cells that make up our adipose tissue, which stores energy as fat. Healthy fat tissue helps provide energy, supports cell growth, protects organs, and keeps the body warm. (Photo by Rogelio Castro/UTHealth)Ĭhanging your eating habits or altering your circadian clock can impact healthy fat tissue throughout your lifespan, according to a preclinical study published today in Nature by researchers with The University of Texas Health Science Center at Houston ( UTHealth). From left to right: Samay Shivshankar, Baharan Fekry, PhD, Kristin Eckel-Mahan, PhD, and Rafael Bravo Santos, PhD. (Photo by Rogelio Castro/UTHealth) Kristin Eckel-Mahan, PhD, and her research team. Throwing off the circadian rhythm and eating a high-fat diet over time will deplete healthy fat cells, and a study led by Kristin Eckel-Mahan, PhD, with UTHealth suggests that this disruption may be difficult to reverse.
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